Chiral Separations: Methods and Protocols (Methods in Molecular Biology) by Gerald Gübitz

Chiral Separations: Methods and Protocols (Methods in Molecular Biology) by Gerald Gübitz
Humana Press; 2004 edition | December 15, 2003 | English | ISBN: 1588291502 | 428 pages | PDF | 6 MB

Many compounds of biological and pharmacological interest are as- metric and show optical activity. Approximately 40% of the drugs in use are known to be chiral and only about 25% are administered as pure enantiomers. It is well established that the pharmacological activity is mostly restricted to one of the enantiomers (eutomer). In several cases, unwanted side effects or even toxic effects may occur with the inactive enantiomer (distomer).